From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation

KS Evans, MH van Wijk, PT McGrath, EC Andersen… - Trends in Genetics, 2021 - cell.com
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …

Genetic approaches for increasing fitness in endangered species

TA Kosch, AW Waddle, CA Cooper, KR Zenger… - Trends in Ecology & …, 2022 - cell.com
The global rate of wildlife extinctions is accelerating, and the persistence of many species
requires conservation breeding programs. A central paradigm of these programs is to …

Genome-wide map** of regulatory variants for temperature-and salinity-adaptive genes reveals genetic basis of genotype-by-environment interaction in …

K Zhang, Q Yang, M Du, Z Zhang, W Wang… - Environmental …, 2023 - Elsevier
Regulatory variants in gene expression serve as bridges linking genetic variation and
phenotypic plasticity. Environmental conditions typically influence the effects of regulatory …

Detecting selection with a genetic cross

HB Fraser - Proceedings of the National Academy of …, 2020 - National Acad Sciences
Distinguishing which traits have evolved under natural selection, as opposed to neutral
evolution, is a major goal of evolutionary biology. Several tests have been proposed to …

Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster

ER Everman, SJ Macdonald - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
Copper is one of a handful of biologically necessary heavy metals that is also a common
environmental pollutant. Under normal conditions, copper ions are required for many key …

WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans

BL Snoek, MG Sterken, M Hartanto… - Database, 2020 - academic.oup.com
Quantitative genetics provides the tools for linking polymorphic loci to trait variation. Linkage
analysis of gene expression is an established and widely applied method, leading to the …

Heat Stress Reduces the Susceptibility of Caenorhabditis elegans to Orsay Virus Infection

Y Huang, MG Sterken, K van Zwet, L van Sluijs… - Genes, 2021 - mdpi.com
The nematode Caenorhabditis elegans has been a versatile model for understanding the
molecular responses to abiotic stress and pathogens. In particular, the response to heat …

Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology

C Braendle, A Paaby - Genetics, 2024 - academic.oup.com
Life history is defined by traits that reflect key components of fitness, especially those relating
to reproduction and survival. Research in life history seeks to unravel the relationships …

The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population

BL Snoek, MG Sterken, H Nijveen, RJM Volkers… - G3, 2021 - academic.oup.com
Studying genetic variation of gene expression provides a powerful way to unravel the
molecular components underlying complex traits. Expression quantitative trait locus (eQTL) …

The genetic architecture underlying body-size traits plasticity over different temperatures and developmental stages in Caenorhabditis elegans

MI Maulana, JAG Riksen, BL Snoek, JE Kammenga… - Heredity, 2022 - nature.com
Most ectotherms obey the temperature-size rule, meaning they grow larger in a colder
environment. This raises the question of how the interplay between genes and temperature …