Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Metastasis requires tumor cell dissemination to different organs from the primary tumor.
Dissemination is a complex cell motility phenomenon that requires the molecular …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …

Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The
mechanisms regulating invadopodium assembly and maturation are not understood. We …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

Invadopodia are proteolytic membrane protrusions formed by highly invasive cancer cells,
commonly observed on substrate (s) mimicking extracellular matrix. Although invadopodia …

Invasive carcinoma cells use specialized actin polymerization–driven protrusions called
invadopodia to degrade and possibly invade through the extracellular matrix (ECM) during …

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …