Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

CD44, a nonkinase single span transmembrane glycoprotein, is a major cell surface
receptor for many other extracellular matrix components as well as classic markers of cancer …

Regenerating islet-derived 4 (REG4) gene was discovered by high-throughput sequencing
of ulcerative colitis cDNA libraries. REG4 is involved in infection and inflammation by …

Colorectal cancer (CRC) is a devastating disease, ranking as the second leading cause of
cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as …

Background: Next to breast cancer, advanced stage metastatic colon cancer represents a
major cause for mortality in women. Germline or somatic mutations in tumor suppressor …

Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical
studies. PDXs offer clear advantages over simpler in vitro cancer models-such as cancer cell …

BACKGROUND Regenerating gene 4 (REG4) has been proved to be carcinogenic in some
cancers, but its manifestation and possible carcinogenic mechanisms in colorectal cancer …

Background and aims The treatment of locally advanced rectal cancer often consists of
neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of …

To clarify the clinicopathological importance of REG4 mRNA expression, we used GEO,
TCGA, xiantao, UALCAN, and Kaplan-Meier plotter for a bioinformatics analysis in breast …

Background Increasing evidence suggests that lncRNA (Long non‐coding RNA, lncRNA)‐
mediated ceRNA (competing endogenous RNA, ceRNA) networks are involved in the …