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Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …
function in tumour suppression, p53 also plays a major role in the response of malignant as …
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
Chronic and acute toxicities of aflatoxins: Mechanisms of action
N Benkerroum - International journal of environmental research and …, 2020 - mdpi.com
There are presently more than 18 known aflatoxins most of which have been insufficiently
studied for their incidence, health-risk, and mechanisms of toxicity to allow effective …
studied for their incidence, health-risk, and mechanisms of toxicity to allow effective …
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …
BCL-2 protein family: attractive targets for cancer therapy
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
Drugging the p53 pathway: understanding the route to clinical efficacy
The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …
The ARTS of p53-dependent mitochondrial apoptosis
The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death,
including apoptosis, through transcription-dependent and transcription-independent …
including apoptosis, through transcription-dependent and transcription-independent …
BH3-mimetic drugs: blazing the trail for new cancer medicines
Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
AF Thomas, GL Kelly, A Strasser - Cell Death & Differentiation, 2022 - nature.com
The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …