RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

DNA not only plays a vital role in nature as fundamental hereditary material for storing
genetic material, but also serves as well-defined functional material, for example, building …

A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …

Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which
affect the lives of hundreds of millions of people, still lack effective and precise treatments. In …

Combining synthetic polymers with RNA paves the way for creating RNA-based materials
with non-canonical functions. We have developed an acylation reagent that allows for direct …

Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and
catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING–NF–κB …

In recent years, the main quest of science has been the pioneering of the groundbreaking
biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids …

Drug-dependent design of hydrogels is currently required for engineering the controlled
release of therapeutics, which is a major contributor to the technical challenges relating to …

Efficient delivery systems for co-delivery of P-glycoprotein (P-gp) inhibitors and
chemotherapeutic drugs are essential for inhibiting multi-drug resistance (MDR) breast …