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Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Alzheimer's amyloid hypothesis and antibody therapy: melting glaciers?
The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily
challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that …
challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that …
Autophagy–lysosomal-associated neuronal death in neurodegenerative disease
RA Nixon - Acta Neuropathologica, 2024 - Springer
Autophagy, the major lysosomal pathway for degrading damaged or obsolete constituents,
protects neurons by eliminating toxic organelles and peptides, restoring nutrient and energy …
protects neurons by eliminating toxic organelles and peptides, restoring nutrient and energy …
[HTML][HTML] Redox homeostasis, gut microbiota, and epigenetics in neurodegenerative diseases: A systematic review
Neurodegenerative diseases encompass a spectrum of disorders marked by the
progressive degeneration of the structure and function of the nervous system. These …
progressive degeneration of the structure and function of the nervous system. These …
Nutritional benefits of lycopene and beta‐carotene: A comprehensive overview
Certain carotene components, such as lycopene and beta‐carotene, are found in tomatoes,
carrots, sweet potatoes, etc. and are good for human health. It gives plants their distinctive …
carrots, sweet potatoes, etc. and are good for human health. It gives plants their distinctive …
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Z Fišar, J Hroudová - Antioxidants, 2024 - mdpi.com
The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD)
is based on the recognition of the primary causes of the disease, which can be deduced …
is based on the recognition of the primary causes of the disease, which can be deduced …
Preparation, characterization, antioxidant activities, and determination of anti-Alzheimer effects of PLGA-based DDSs containing ferulic acid
Nanoparticle (NP) systems have attracted the attention of researchers in recent years due to
their advantages, such as modified release features, increased therapeutic efficacy, and …
their advantages, such as modified release features, increased therapeutic efficacy, and …
Differential roles of regulatory T cells in Alzheimer's disease
Regulatory T (Treg) cells interact with a variety of resident cells and infiltrated immune cells
in the central nervous system (CNS) to modulate neuroinflammation and …
in the central nervous system (CNS) to modulate neuroinflammation and …
Hindlimb immobilization induces insulin resistance and elevates mitochondrial ROS production in the hippocampus of female rats
NR Kerr, CW Mossman, CH Chou… - Journal of Applied …, 2024 - journals.physiology.org
Alzheimer's disease (AD) is the fifth leading cause of death in older adults, and treatment
options are severely lacking. Recent findings demonstrate a strong relationship between …
options are severely lacking. Recent findings demonstrate a strong relationship between …
The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease
J Hu, B Huang, K Chen - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Introduction Alzheimer's disease (AD), a major cause of dementia globally, imposes
significant societal and personal costs. This review explores the efficacy of physical exercise …
significant societal and personal costs. This review explores the efficacy of physical exercise …