Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Alzheimer's amyloid hypothesis and antibody therapy: melting glaciers?

PF Høilund-Carlsen, A Alavi, RJ Castellani… - International journal of …, 2024 - mdpi.com
The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily
challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that …

Autophagy–lysosomal-associated neuronal death in neurodegenerative disease

RA Nixon - Acta Neuropathologica, 2024 - Springer
Autophagy, the major lysosomal pathway for degrading damaged or obsolete constituents,
protects neurons by eliminating toxic organelles and peptides, restoring nutrient and energy …

[HTML][HTML] Redox homeostasis, gut microbiota, and epigenetics in neurodegenerative diseases: A systematic review

C Munteanu, AI Galaction, M Turnea, CD Blendea… - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases encompass a spectrum of disorders marked by the
progressive degeneration of the structure and function of the nervous system. These …

Nutritional benefits of lycopene and beta‐carotene: A comprehensive overview

T Tufail, H Bader Ul Ain, S Noreen… - Food Science & …, 2024 - Wiley Online Library
Certain carotene components, such as lycopene and beta‐carotene, are found in tomatoes,
carrots, sweet potatoes, etc. and are good for human health. It gives plants their distinctive …

CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease

Z Fišar, J Hroudová - Antioxidants, 2024 - mdpi.com
The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD)
is based on the recognition of the primary causes of the disease, which can be deduced …

Preparation, characterization, antioxidant activities, and determination of anti-Alzheimer effects of PLGA-based DDSs containing ferulic acid

KN Arınmış, HT Kıyan, AA Ozturk - ACS omega, 2024 - ACS Publications
Nanoparticle (NP) systems have attracted the attention of researchers in recent years due to
their advantages, such as modified release features, increased therapeutic efficacy, and …

Differential roles of regulatory T cells in Alzheimer's disease

A Jafarzadeh, A Sheikhi, Z Jafarzadeh, M Nemati - Cellular immunology, 2023 - Elsevier
Regulatory T (Treg) cells interact with a variety of resident cells and infiltrated immune cells
in the central nervous system (CNS) to modulate neuroinflammation and …

Hindlimb immobilization induces insulin resistance and elevates mitochondrial ROS production in the hippocampus of female rats

NR Kerr, CW Mossman, CH Chou… - Journal of Applied …, 2024 - journals.physiology.org
Alzheimer's disease (AD) is the fifth leading cause of death in older adults, and treatment
options are severely lacking. Recent findings demonstrate a strong relationship between …

The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease

J Hu, B Huang, K Chen - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Introduction Alzheimer's disease (AD), a major cause of dementia globally, imposes
significant societal and personal costs. This review explores the efficacy of physical exercise …