The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Disuse osteoporosis describes a state of bone loss due to local skeletal unloading or
systemic immobilization. This review will discuss advances in the field that have shed light …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Stem cell differentiation is of great interest in medical research; however, specifically and
effectively regulating stem cell differentiation is still a challenge. In addition to chemical …

Electrical stimulation can effectively accelerate bone healing. However, the substantial size
and weight of electrical stimulation devices result in reduced patient benefits and …

Piezo channels are mechanosensitive ion channels located in the cell membrane and
function as key cellular mechanotransducers for converting mechanical stimuli into …

Macrophages are multifunctional immune system cells that are essential for the mechanical
stimulation‐induced control of metabolism. Piezo1 is a non‐selective calcium channel …

Background Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc
degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense the changes in …