Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …

Transient receptor potential (TRP) channels have been increasingly implicated in the
pathological mechanisms of CNS disorders. TRP expression has been detected in neurons …

Chronic neuroinflammation driven by microglia is a characteristic feature associated with
numerous neurodegenerative diseases. While acute inflammation can assist with recovery …

Abstract TRPM2 is a Ca 2+-permeable non-selective cation channel that uniquely is
activated by intracellular ADP-ribose. To date, only one pharmacological blocker of this …

The effects of epigallocatechin gallate (EGCG) on the phosphoinositide 3-kinase (PI3K)/Akt
and glycogen synthase kinase-3 (GSK-3) pathway during oxidative-stress-induced injury …

Minocycline has been shown to have remarkably neuroprotective qualities, but underlying
mechanisms remain elusive. We reported here the robust neuroprotection by minocycline …

The phenolic glucoside gastrodin (Gas) is a main component extracted from the rhizome of
Gastrodia elata, a Chinese herbal medicine, which has long been used for treating …

Depression is a major emotional disorder that has a detrimental effect on quality of life. The
chronic mild stress (CMS)-depression model was adopted in rats to evaluate the …

Oxidative stress plays critical roles in the pathogenic mechanisms of several
neurodegenerative disorders including Alzheimer's disease (AD), thus much research effort …

Clotrimazole is an FDA approved drug and is widely used as an antifungal agent. An
extensive body of research is available about its mechanism of action on various cell types …