Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Glutamate, released at a majority of excitatory synapses in the central nervous system,
depolarizes neurons by acting at specific receptors. Its action is terminated by removal from …

The finding that astrocytes possess glutamate-sensitive ion channels hinted at a previously
unrecognized signaling role for these cells. Now it is reported that cultured hippocampal …

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

The circuitry of the human brain is formed by neuronal networks embedded into astroglial
syncytia. The astrocytes perform numerous functions, providing for the overall brain …

Astrocytes are often referred to, and historically have been regarded as, support cells of the
mammalian CNS. Work over the last decade suggests otherwise—that astrocytes may in fact …

The concept of a metabolic coupling between neurons and glia, particularly astrocytes,
geared at maintaining energy metabolism homeostasis in the brain has been entertained for …

Using an antibody highly specific for D-serine conjugated to glutaraldehyde, we have
localized endogenous D-serine in rat brain. Highest levels of D-serine immunoreactivity …

Despite striking advances in functional brain imaging, the cellular and molecular
mechanisms that underlie the signals detected by these techniques are still largely …