Precision medicine requires individualized modeling of disease and drug dynamics, with
machine learning-based computational techniques gaining increasing popularity. The …

Background Rivaroxaban is an oral anticoagulant widely used for stroke prevention in
patients with non-valvular atrial fibrillation (NVAF). During long-term anticoagulant therapy …

Background and purpose CYP2C19 is a key factor influencing escitalopram (SCIT)
exposure. However, different studies reported various results. This study aims to develop a …

Medication nonadherence is one of the largest problems in healthcare today, particularly for
patients undergoing long-term pharmacotherapy. To combat nonadherence, it is often …

Objective Delayed or missed doses are unavoidable in the pharmacotherapy of epilepsy
and significantly compromise the efficacy of antiepileptic drug treatment. An inappropriate …

Nonadherence to medication is a major public health problem. To combat nonadherence,
some clinicians have suggested using “forgiving” drugs, which maintain efficacy in spite of …

Background and Objectives Delayed or missed antiseizure medications (ASMs) doses are
common during long-term or lifelong antiepilepsy treatment. This study aims to explore …

Abstract Background and Objective Nonadherence to levetiracetam (LEV) use can result in
subtherapeutic concentrations and increase the risk of the occurrence of seizures. The …

Medication adherence is a well-known problem for pharmaceutical treatment of chronic
diseases. Understanding how nonadherence affects treatment efficacy is made difficult by …

Medication adherence is a major problem for patients with chronic diseases that require
long term pharmacotherapy. Many unanswered questions surround adherence, including …