Proteolytic enzymes are key signaling molecules in both normal physiological processes
and various diseases. After synthesis, protease activity is tightly controlled. Consequently …

The trypanosomiases consist of a group of important animal and human diseases caused by
parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the …

A comparison of gene content and genome architecture of Trypanosoma brucei,
Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles …

Trypanosomatids are protozoan parasites of the class Kinetoplastida predominately
restricted to invertebrate hosts (ie possess a monoxenous life-cycle). However, several …

Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …

Five years ago, little was known about kinetoplastid evolution. Recent improvements in the
taxon sampling for nuclear rRNA genes and several protein markers have transformed this …

The ancestor of Trypanosome cruzi was probably introduced to South American via bats
approximately 7-10 million years ago. When the first humans arrived in the New World, a …

We characterized 15 Trypanosoma cruzi isolates from bats captured in the Amazon, Central
and Southeast Brazilian regions. Phylogenetic relationships among T. cruzi lineages using …

Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Simple phylogenetic tests were applied to a large data set of nucleotide sequences from two
nuclear genes and a region of the mitochondrial genome of Trypanosoma cruzi, the agent of …