Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …

The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …

The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …

Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …

Cancer cells adapt to their inherently increased oxidative stress through activation of the
glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems …

Purpose Cancer, a major public health problem, exhibits significant redox alteration.
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …

Thioredoxin reductase (TrxR) participates in the regulation of redox reactions in organisms.
It works mainly via its substrate molecule, thioredoxin, to maintain the redox balance and …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-
dependent system. An equally important function of this system is the regulation of the …