The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Zebrafish (Danio rerio) is an emerging toxicity screening model for both human health and
ecology. As part of the Computational Toxicology Research Program of the US EPA, the …

BACKGROUND: A zebrafish (Danio rerio) teratogenicity assay has been developed and
evaluated for its ability to predict the teratogenic potential of chemicals. METHODS …

The zebrafish is increasingly used as a vertebrate animal model for in vivo drug discovery
and for assessing chemical toxicity and safety. Numerous studies have confirmed that …

Background In the drug discovery pipeline, safety pharmacology is a major issue. The
zebrafish has been proposed as a model that can bridge the gap in this field between cell …

Zebrafish embryos have been shown to be a useful model for the detection of direct acting
teratogens. This communication presents a protocol for a 3-day in vitro zebrafish embryo …

Autophagy mediates the bulk turnover of cytoplasmic constituents in lysosomes. During
embryonic development in animals, a dramatic degradation of yolk proteins and synthesis of …

Anecdotal evidence has long suggested that zebrafish may be a good model to predict
toxicity of human drugs. As summarized in this review, several groups have recently …

The zebrafish is a powerful whole animal model which is complementary to in vitro and
mammalian models. It has been shown to be applicable to the high-throughput behavioral …