Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Pain is an integrative phenomenon that results from dynamic interactions between sensory
and contextual (ie, cognitive, emotional, and motivational) processes. In the brain the …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Pain is considered a multidimensional experience that embodies not merely sensation, but
also emotion and perception. As is appropriate for this complexity, pain is represented and …

It has been proposed that pain competes with other attention-demanding stimuli for cognitive
resources, and many chronic pain patients display significant attention and mental flexibility …

Thalamocortical dysrhythmia is a key pathology of chronic neuropathic pain, but few studies
have investigated thalamocortical networks in chronic low back pain (cLBP) given its non …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …