According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

Mucin-type O-linked glycoproteins are involved in a variety of biological interactions in
higher eukaryotes. The biosynthesis of these glycoproteins is initiated by a family of …

Proteomics is the systematic study of the many and diverse properties of proteins in a
parallel manner with the aim of providing detailed descriptions of the structure, function and …

Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …