Adolescence as a neurobiological critical period for the development of higher-order cognition
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …
order cognitive abilities and corresponding refinements of the structure and function of the …
Critical period plasticity in local cortical circuits
TK Hensch - Nature Reviews Neuroscience, 2005 - nature.com
Neuronal circuits in the brain are shaped by experience during'critical periods' in early
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …
Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons
Cortical inhibitory neurons contact each other to form a network of inhibitory synaptic
connections. Our knowledge of the connectivity pattern underlying this inhibitory network is …
connections. Our knowledge of the connectivity pattern underlying this inhibitory network is …
Cortical interneurons that specialize in disinhibitory control
In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division
of labour subserving distinct modes of inhibitory control,,,,,,. A unique mode of inhibitory …
of labour subserving distinct modes of inhibitory control,,,,,,. A unique mode of inhibitory …
[HTML][HTML] Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …
[HTML][HTML] Development and plasticity of the primary visual cortex
Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
Balancing plasticity/stability across brain development
AE Takesian, TK Hensch - Progress in brain research, 2013 - Elsevier
The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
A highly diverse population of neocortical GABAergic inhibitory interneurons has been
implicated in multiple functions in information processing within cortical circuits. The diversity …
implicated in multiple functions in information processing within cortical circuits. The diversity …
Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition?
GABAergic interneurons play a major role in the function of the mammalian neocortex, but
their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate …
their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate …
[HTML][HTML] Genetic dissection of neural circuits
Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …
characterization of the participating cell types and their connections, and the ability to …