Abstract Subjective Cognitive Decline (SCD) in older adults has been identified as a risk
factor for dementia, although the literature is inconsistent, and it is unclear which factors …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological
hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

There is increasing evidence that subjective cognitive decline (SCD) in individuals with
unimpaired performance on cognitive tests may represent the first symptomatic …

Older adults with subjective cognitive decline (SCD) in the absence of objective
neuropsychological dysfunction are increasingly viewed as at risk for non-normative …

Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the
Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Introduction: Alzheimer's disease (AD) is characterized by cerebral glucose
hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the …