Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

Many peptide hormones form an α-helix on binding their receptors,,–, and sensitive methods
for their detection could contribute to better clinical management of disease. De novo protein …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …

Recent developments in computational chemistry and biology have come together in the
“inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze …

The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …

The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …

Integrins are α/β heterodimeric adhesion glycoprotein receptors that regulate a wide variety
of dynamic cellular processes such as cell migration, phagocytosis, and growth and …