Technological advances have made it possible to study a patient from multiple angles with
high-dimensional, high-throughput multiscale biomedical data. In oncology, massive …

Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …

Drug-resistant cancer spheroids were fabricated by three-dimensional (3D) bioprinting for
the quantitative evaluation of drug resistance of cancer cells, which is a very important issue …

One of the most frequently utilized cancer stem cell markers in human cancers, including
colorectal cancer and breast cancer, is CD44. A glycoprotein, CD44, traverses the cell …

Cancer organoids generated from 3D in vitro cell cultures have contributed to the study of
drug resistance. Maintenance of genomic and transcriptomic similarity between organoids …

2D culture as a model for drug testing often turns to be clinically futile. Therefore, 3D cultures
(3Ds) show potential to better model responses to drugs observed in vivo. In preliminary …

Background Cervical cancer (CC) is a disease that affects female health; therefore, timely
prevention and diagnosis of CC are crucial to decrease its mortality. Ferroptosis, an iron …