Methodological differences between in vitro and in vivo studies on cartilage overloading
complicate the comparison of outcomes. The rationale of the current review was to (i) identify …

Cracks in articular cartilage compromise tissue integrity and mechanical properties and lead
to chondral lesions if untreated. An understanding of the mechanics of cracked cartilage may …

Degeneration of articular cartilage is often triggered by a small tissue crack. As cartilage
structure and composition change with age, the mechanics of cracked cartilage may depend …

Osteochondral allograft (OCA) transplantation offers an attractive treatment option as it can
be used to repair large cartilage defects that otherwise would not heal. The currently …

Impact loading results in chondrocyte death. Previous studies implicated high tensile strain
rates in chondrocyte membranes as the cause of impact‐induced cell deaths. However, this …

Cartilage cracks disrupt tissue mechanics, alter cell mechanobiology, and often trigger
tissue degeneration. Yet, some tissue cracks heal spontaneously. A primary factor …

Chondrocytes, the resident cells in articular cartilage, carry the burden of producing and
maintaining the extracellular matrix (ECM). However, as these cells have a low proliferative …

Cyclic mechanical loading of cartilage induces stresses and fluid flow, which are thought to
modulate chondrocyte metabolism. The uneven surface, plus the heterogeneity of cartilage …

Articular cartilage (AC) is a kind of connective tissue that wraps the surfaces of long bones in
diarthrodial joints and serves a vital function in the human body. Damaged cartilage has low …

Background: Knee joint osteoarthritis is a highly disabling disease with no distinct cause that
persists unabated despite decades of research. Among the various possible causes and …