Mucins as multifunctional building blocks of biomaterials

G Petrou, T Crouzier - Biomaterials science, 2018 - pubs.rsc.org
Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the
surfaces of many cell types and can be secreted to form mucus gels that assume important …

Purified mucins in drug delivery research

M Marczynski, C Kimna, O Lieleg - Advanced Drug Delivery Reviews, 2021 - Elsevier
One of the main challenges in the field of drug delivery remains the development of
strategies to efficiently transport pharmaceuticals across mucus barriers, which regulate the …

Development of tofacitinib loaded pH-responsive chitosan/mucin based hydrogel microparticles: In-vitro characterization and toxicological screening

RT Malatani, S Bilal, A Mahmood, RM Sarfraz, N Zafar… - Gels, 2023 - mdpi.com
Tofacitinib is an antirheumatic drug characterized by a short half-life and poor permeability,
which necessitates the development of sustained release formulation with enhanced …

Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes …

FC Kenechukwu, DO Nnamani, JC Duhu… - Heliyon, 2022 - cell.com
Metformin hydrochloride (MH) is a widely used oral biguanide antihyperglycemic
(antidiabetic) drug with poor bioavailability which necessitates the development of novel …

[HTML][HTML] Physicochemical, mechanical and thermal analysis of unfired clay bricks: Kaolinite-PEG 6000 composite

R Et-tanteny, B El Amrani, I Manssouri… - Cleaner Engineering and …, 2024 - Elsevier
This study aims to evaluate the potential of polyethylene glycol (PEG 6000), a recycled
material, as an additive to improve unfired clay bricks. By proposing a sustainable …

Bioactive glass incorporated dressing matrix for rapid hemostatic action with antibacterial activity

P Roy, R Saha, D Dattaray, S Saha, TK Mandal… - Materials Chemistry and …, 2024 - Elsevier
Uncontrolled bleeding stands as a leading cause of preventable death in both civilian
trauma and military battlefield scenarios. Existing hemostatic dressings like HemCon, Celox …

Novel intravaginal drug delivery system based on molecularly PEGylated lipid matrices for improved antifungal activity of miconazole nitrate

FC Kenechukwu, AA Attama, EC Ibezim… - BioMed Research …, 2018 - Wiley Online Library
The aim of this study was to investigate the potential of microparticles based on
biocompatible phytolipids [Softisan® 154 (SF)(hydrogenated palm oil) and super‐refined …

Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin

C Umeyor, A Attama, E Uronnachi… - International Journal of …, 2016 - Elsevier
Self-nanoemulsifying formulations (SNEFs) structured with PEG 4000 as PEGylated SNEFs,
were formulated after solubility studies using rational blends of soybean oil, a combination of …

Fucoidan coated liposomes loaded with novel antituberculosis agent: preparation, evaluation, and cytotoxicity study

MM Obiedallah, VV Melekhin… - Pharmaceutical …, 2024 - Taylor & Francis
In this article, we described a novel antituberculosis imidazotetrazine derivative designed in
fucoidan-coated liposomes to reduce its cytotoxicity and investigate its mucoadhesive …

Achatina fulica haemocyanin-derived peptides as novel antimicrobial agents

AE Pereira, L Suarez, T Roman, F Guzmán, L Sierra… - Biochimie, 2024 - Elsevier
Haemocyanin-derived peptides were previously found in semi-purified fractions of mucus
secretion from the snail Achatina fulica, which exhibited an inhibitory effect on …