Autoimmune uveitis is a non-infectious intraocular condition that affects the uveal tract of the
eye and threatens vision if not treated properly. Increasing evidence suggests that activated …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes
cytoplasmic nucleic acids to activate the innate immune responses via generation of the …

Uveitis is a severe autoimmune disease, and a common cause of blindness; however, its
individual cellular dynamics and pathogenic mechanism remain poorly understood. Herein …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …

The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in
response to double-stranded DNA and functions as an adaptor molecule for type I IFN (IFNI) …

Introduction Gut microbiota plays a critical role in the regulation of immune homeostasis.
Accordingly, several autoimmune disorders have been associated with dysbiosis in the gut …

As the crucial components of immunity, T cell populations serve as the most multipotent
force in exerting adaptive immunity for either providing protective reaction against …

Background Induction of autoantigen-specific Treg cells that suppress tissue-specific
autoimmunity without compromising beneficial immune responses is the holy-grail for …

Background The mechanisms underlying the known link between overweight/obesity and
childhood asthma are unclear. We aimed to identify differentially expressed genes and …

Autoimmune uveitis refers to several intraocular inflammation conditions, which are
mediated by autoreactive T cells. Regulatory T cells (Tregs) are immunosuppressive cells …