Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

H Lu, T Hong, Y Jiang, M Whiteway, S Zhang - Advanced Drug Delivery …, 2023 - Elsevier
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease

M Hoenigl, A Arastehfar, MC Arendrup… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …

Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

MG Kim, MG Kang, MG Lee, SJ Yang… - Journal of Clinical …, 2023 - Wiley Online Library
Aim The incidence of fungal sinusitis is increasing; however, its pathophysiology has not
been investigated previously. We investigate the effect of periodontitis on the incidence of …

Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease

L Cai, P Gao, Z Wang, C Dai, Y Ning, M Ilkit… - Frontiers in …, 2022 - frontiersin.org
Species within the Aspergillus spp. cause a wide range of infections in humans, including
invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic …

Harnessing bioengineered myeloid progenitors for precision immunotherapies

W Buys, ET Zambidis - npj Regenerative Medicine, 2023 - nature.com
Granulocytes and macrophages are the frontline defenders of the innate immune system.
These myeloid cells play a crucial role in not only eliminating pathogens and tumor cells, but …

How are granulocytes for transfusion best used? The past, the present and the future

S Morton, K Fleming… - British Journal of …, 2023 - Wiley Online Library
Granulocyte transfusions continue to be used in clinical practice, predominantly for treatment
of refractory infection in the setting of severe neutropenia. There is biological plausibility for …

Neutrophil swarming is crucial for limiting oral mucosal infection by Candida albicans

D Saraswat, IG Rojas, R Kumar, R Li… - Journal of Leukocyte …, 2024 - academic.oup.com
Oral mucosal colonization by Candida albicans is benign in healthy people but progresses
to deeper infection, known as oropharyngeal candidiasis, that may become disseminated …

Neutrophil generation from hematopoietic progenitor cells and induced pluripotent stem cells (iPSCs): Potential applications

A Jafarzadeh, M Motaghi, SK Patra, Z Jafarzadeh… - Cytotherapy, 2024 - Elsevier
Neutrophils are the most frequent immune cell type in peripheral blood, performing an
essential role against pathogens. People with neutrophil deficiencies are susceptible to …

Virus-associated fungal infections and lost immune resistance

N Sarden, BG Yipp - Trends in Immunology, 2023 - cell.com
Invasive fungal infections are an increasing threat to human health. Of recent concern is the
emergence of influenza-or SARS-CoV-2-virus-associated invasive fungal infections …