Current and future perspectives of liquid biopsies in genomics-driven oncology
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
Bridging biological cfDNA features and machine learning approaches
T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …
revolutionize precision oncology and blood-based cancer screening. Recent technological …
Toward the early detection of cancer by decoding the epigenetic and environmental fingerprints of cell-free DNA
Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Current evidence suggests that plasma cell-free DNA (cfDNA) is fragmented around a mode
of 166 bp. Data supporting this view has been mainly acquired through the analysis of …
of 166 bp. Data supporting this view has been mainly acquired through the analysis of …
The potential of liquid biopsies for the early detection of cancer
Precision medicine refers to the choosing of targeted therapies based on genetic data. Due
to the increasing availability of data from large-scale tumor genome sequencing projects …
to the increasing availability of data from large-scale tumor genome sequencing projects …
New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis
C Sanchez, MW Snyder, R Tanos, J Shendure… - NPJ genomic …, 2018 - nature.com
Circulating cell-free DNA (cfDNA) has received increasing interest as an apparent
breakthrough approach in diagnostics, personalized medicine, and tumor biology. However …
breakthrough approach in diagnostics, personalized medicine, and tumor biology. However …
Leveraging the fragment length of circulating tumour DNA to improve molecular profiling of solid tumour malignancies with next-generation sequencing: a pathway to …
HR Underhill - Molecular diagnosis & therapy, 2021 - Springer
Circulating cell-free DNA (ccfDNA) has emerged as a promising diagnostic tool in oncology.
Identification of tumour-derived ccfDNA (ie circulating tumour DNA [ctDNA]) provides non …
Identification of tumour-derived ccfDNA (ie circulating tumour DNA [ctDNA]) provides non …
Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients
We examined from a large exploratory study cohort of COVID-19 patients (N= 549) a
validated panel of neutrophil extracellular traps (NETs) markers in different categories of …
validated panel of neutrophil extracellular traps (NETs) markers in different categories of …
A review on the impact of single-stranded library preparation on plasma cell-free diversity for cancer detection
In clinical oncology, cell-free DNA (cfDNA) has shown immense potential in its ability to
noninvasively detect cancer at various stages and monitor the progression of therapy …
noninvasively detect cancer at various stages and monitor the progression of therapy …