The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

The RecQ helicases are conserved from bacteria to humans and play a critical role in
genome stability. In humans, loss of RecQ gene function is associated with cancer …

Topoisomerase I (Top1) is a key enzyme in functioning at the interface between DNA
replication, transcription and mRNA maturation. Here, we show that Top1 suppresses …

ABSTRACT G-rich genomic regions can form G4 DNA upon transcription or replication. We
have quantified the potential for G4 DNA formation (G4P) of the 16 654 genes in the human …

Guanine rich DNA has been known for decades to form unusual structures, although their
biological relevance was little understood. Recent advances have demonstrated that …

Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to
preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased …

Recent developments in micro-and nanotechnologies made possible the fabrication of
devices integrating a deterministic network of nanochannels, ie, with at least one dimension …

Homologous recombination (HR) is crucial for maintaining genome integrity by repairing
DNA double-strand breaks (DSBs) and rescuing collapsed replication forks. In contrast …

THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian
THO in these processes is uncertain, which suggests a differential implication of mRNP …

Homologous recombination safeguards genome integrity, but it can also cause genome
instability of important consequences for cell proliferation and organism development …