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The logic devices for biomolecular computing: Progress, strategies, and future directions
Nucleic acid-based programmable devices connect the fields of computation and biology.
The synthesis, stability, and molecular hybridization are paramount data storage capabilities …
The synthesis, stability, and molecular hybridization are paramount data storage capabilities …
Selection platforms for directed evolution in synthetic biology
Life on Earth is incredibly diverse. Yet, underneath that diversity, there are a number of
constants and highly conserved processes: all life is based on DNA and RNA; the genetic …
constants and highly conserved processes: all life is based on DNA and RNA; the genetic …
Designing drugs that overcome antibacterial resistance: where do we stand and what should we do?
Introduction: In recent years, infections caused by multidrug-resistant bacterial pathogens
have become a huge issue to public healthcare systems. Indeed, the misuse of antibiotics …
have become a huge issue to public healthcare systems. Indeed, the misuse of antibiotics …
Targeting TPP riboswitches using chimeric antisense oligonucleotide technology for antibacterial drug development
M Traykovska, LA Otcheva… - ACS Applied Bio …, 2022 - ACS Publications
Nowadays, the emergence and the transmission of multidrug-resistant pathogenic bacteria
are a severe menace mounting a lot of pressure on the healthcare systems worldwide. Many …
are a severe menace mounting a lot of pressure on the healthcare systems worldwide. Many …
[HTML][HTML] Bioinformatics and genomic analyses of the suitability of eight riboswitches for antibacterial drug targets
N Pavlova, R Penchovsky - Antibiotics, 2022 - mdpi.com
Antibiotic resistance (AR) is an acute problem that results in prolonged and debilitating
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …
FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing
Z **ang, JY Zheng, X Ma, Y Chu, Q Song… - Chemical …, 2024 - pubs.rsc.org
This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and
4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification …
4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification …
Genome-wide bioinformatics analysis of FMN, SAM-I, glmS, TPP, lysine, purine, cobalamin, and SAH riboswitches for their applications as allosteric antibacterial drug …
N Pavlova, R Penchovsky - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
Objectives: A constantly growing number of antibiotic-resistant strains of human pathogenic
bacteria is an acute problem. Prolonged illnesses and increasing mortality worldwide mean …
bacteria is an acute problem. Prolonged illnesses and increasing mortality worldwide mean …
Coulovoltammetric and dynamovoltammetric responses from conducting polymers and bilayer muscles as tools to identify reaction-driven structural changes. A review
TF Otero - Electrochimica Acta, 2016 - Elsevier
Coulovoltammetric (charge-potential) responses to potential cycles are reviewed here as a
powerful tool for the characterization of reaction-driven structural changes (conformational …
powerful tool for the characterization of reaction-driven structural changes (conformational …
Ligand‐dependent ribozymes
M Felletti, JS Hartig - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened
the horizon of RNA‐based functions in natural systems. Similarly to the activity of protein …
the horizon of RNA‐based functions in natural systems. Similarly to the activity of protein …
Application of artificial neural networks in modern drug discovery
V Mandlik, PR Bejugam, S Singh - Artificial neural network for drug design …, 2016 - Elsevier
Artificial neural networks are abstract models that mimic the complex structure and
functioning of the brain. They are widely being used in the fields of systems biology and drug …
functioning of the brain. They are widely being used in the fields of systems biology and drug …