Randomised controlled trials, including the National Lung Screening Trial (NLST) and the
NELSON trial, have shown reduced mortality with lung cancer screening with low-dose CT …

Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is
responsible for the majority of cancer-related deaths worldwide. The management of …

Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

Background Individual plasma proteins have been identified as minimally invasive
biomarkers for lung cancer diagnosis with potential utility in early detection. Plasma …

Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for
cancer prevention. We investigate 2,074 circulating proteins and risk of nine common …

The availability of protein measurements and whole exome sequence data in the UK
Biobank enables investigation of potential observational and genetic protein-cancer risk …

Low-dose computed tomography (LDCT) screening for lung cancer substantially reduces
mortality from lung cancer, as revealed in randomized controlled trials and meta-analyses …

Background Lung cancer risk prediction models might efficiently identify individuals who
should be offered lung cancer screening. However, their performance has not been …

Identification of risk biomarkers may enhance early detection of smoking-related lung
cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most …

Background We sought to develop a proteomics-based risk model for lung cancer and
evaluate its risk-discriminatory performance in comparison with a smoking-based risk model …