The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

BACKGROUND How do the different cell types in our bodies maintain their distinctive and
characteristic sizes? Although much is known about the signaling networks that stimulate or …

How cells control their size and maintain size homeostasis is a fundamental open question.
Cell-size homeostasis has been discussed in the context of two major paradigms:" sizer," in …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

An adult animal consists of cells of vastly different size and activity, but the regulation of cell
size remains poorly understood. Recent studies uncovering some of the signaling pathways …

Highlights•Microfluidic devices allow controlling culture conditions in the microscale.•They
have high potential for automation and parallelization, and facilitate simultaneous …

Despite decades of research, how mammalian cell size is controlled remains unclear
because of the difficulty of directly measuring growth at the single-cell level. Here we report …

Metastasis requires the penetration of cancer cells through tight spaces, which is mediated
by the physical properties of the cells as well as their interactions with the confined …

It has long been proposed that the cell cycle is regulated by physical forces at the cell–cell
and cell–extracellular matrix (ECM) interfaces,,,,,,,,,,–. However, the evolution of these forces …

To achieve a stable size distribution over multiple generations, proliferating cells require a
means of counteracting stochastic noise in the rate of growth, the time spent in various …