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Osteocytes in bone aging: Advances, challenges, and future perspectives
Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …
response to hormones and mechanical loading. Substantial evidence have demonstrated …
[HTML][HTML] Interactions between muscle and bone—where physics meets biology
Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …
Physical forces are generated through gravity, locomotion, exercise, and external devices …
The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture
Organisms rely on mechanosensing mechanisms to adapt to changes in their mechanical
environment. Fluid-filled network structures not only ensure efficient transport but can also …
environment. Fluid-filled network structures not only ensure efficient transport but can also …
[PDF][PDF] The effect of six weeks' progressive resistance training on hippocampus BDNF gene expression and serum changes of TNF-α in diabetic wistar rats
Background and Purpose: Alzheimer's disease (AD) is associated with decreases in
neurons in several important areas for memory and learning in the brain, especially in the …
neurons in several important areas for memory and learning in the brain, especially in the …
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …
mechanisms underlying the concurrent decline in bone mass, quality, and …
Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice
Aging diminishes bone formation engendered by mechanical loads, but the mechanism for
this impairment remains unclear. Because Wnt signaling is required for optimal loading …
this impairment remains unclear. Because Wnt signaling is required for optimal loading …
Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish
Exercise promotes gain in bone mass through adaptive responses of the vertebrate
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …
[HTML][HTML] The effect of eight weeks resistance and endurance training on some angiogenesis factors of hippocampus tissue in male wistar rats
Purpose: One of the cause of adaptations due to exercise training is increased capillary
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …
Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes
The adaptation of the skeleton to its mechanical environment is orchestrated by
mechanosensitive osteocytes, largely by regulating the abundance of sclerostin, a secreted …
mechanosensitive osteocytes, largely by regulating the abundance of sclerostin, a secreted …
[HTML][HTML] Mechanoregulation analysis of bone formation in tissue engineered constructs requires a volumetric method using time-lapsed micro-computed tomography
Bone can adapt its microstructure to mechanical loads through mechanoregulation of the
(re) modeling process. This process has been investigated in vivo using time-lapsed micro …
(re) modeling process. This process has been investigated in vivo using time-lapsed micro …