Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin
resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes …

The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

With rapid lifestyle transitions, the increasing burden of nonalcoholic fatty liver disease
(NAFLD) in China has emerged as a major public health issue. To obtain a comprehensive …

Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and
fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and …

Most kidney cancers are metabolically dysfunctional,,–, but how this dysfunction affects
cancer progression in humans is unknown. We infused 13C-labelled nutrients in over 80 …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …