Circulating miRNA analysis for cancer diagnostics and therapy

L Valihrach, P Androvic, M Kubista - Molecular aspects of medicine, 2020 - Elsevier
Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer–a comprehensive review

KL Reese, K Pantel, DJ Smit - Journal of Experimental & Clinical Cancer …, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is frequently detected in late stages, which leads
to limited therapeutic options and a dismal overall survival rate. To date, no robust method …

Dual-mode SERS and electrochemical detection of miRNA based on popcorn-like gold nanofilms and toehold-mediated strand displacement amplification reaction

H Zhou, J Zhang, B Li, J Liu, JJ Xu… - Analytical chemistry, 2021 - ACS Publications
MicroRNA (miRNA) has emerged as one of the ideal target biomarker analytes for cancer
detection because its abnormal expression is closely related to the occurrence of many …

Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis

L Sun, W Zhu, P Zhao, Q Wang, B Fan, Y Zhu… - Cell death & …, 2020 - nature.com
Exosomes (Exo) secreted from mesenchymal stem cells (hMSCs) are protective against
myocardial injury. The purpose of the study was to investigate the role and mechanisms by …

Considerations and suggestions for the reliable analysis of miRNA in plasma using qRT-PCR

E Ban, EJ Song - Genes, 2022 - mdpi.com
MicroRNAs (miRNAs) are promising molecules that can regulate gene expression, and their
expression level and type have been associated with early diagnosis, targeted therapy, and …

[HTML][HTML] Biomarkers and lung cancer early detection: state of the art

E Dama, T Colangelo, E Fina, M Cremonesi… - Cancers, 2021 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer death worldwide. Detecting
lung malignancies promptly is essential for any anticancer treatment to reduce mortality and …

Platelet removal from human blood plasma improves detection of extracellular vesicle‐associated miRNA

JWP Bracht, M Los, MAJ van Eijndhoven… - Journal of …, 2023 - Wiley Online Library
Human blood plasma prepared by centrifugation contains not only extracellular vesicles
(EVs) but also platelets and erythrocyte ghosts (ery‐ghosts). Here we studied whether …

International liquid biopsy standardization alliance white paper

D Connors, J Allen, JD Alvarez, J Boyle… - Critical reviews in …, 2020 - Elsevier
The promise of precision medicine as a model to customize health care to the individual
patient is heavily dependent upon new genetic tools to classify and characterize diseases …

Quantitative or digital PCR? A comparative analysis for choosing the optimal one for biosensing applications

H Zhang, L Cao, J Brodsky, I Gablech, F Xu, Z Li… - TrAC Trends in …, 2024 - Elsevier
This paper offers an exhaustive comparison of quantitative PCR (qPCR) and digital PCR
(dPCR) technologies, focusing on their critical roles in molecular diagnostics, ranging from …

Plasma microRNAs as potential biomarkers in early Alzheimer disease expression

C Peña-Bautista, A Tarazona-Sánchez… - Scientific Reports, 2022 - nature.com
The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their
involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new …