Ultrasound‐activated probiotics vesicles coating for titanium implant infections through bacterial cuproptosis‐like death and immunoregulation
Implant‐associated infections (IAIs) are the main cause of prosthetic implant failure.
Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in …
Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in …
Microorganism microneedle micro-engine depth drug delivery
B Zheng, Q Li, L Fang, X Cai, Y Liu, Y Duo, B Li… - Nature …, 2024 - nature.com
As a transdermal drug delivery method, microneedles offer minimal invasiveness,
painlessness, and precise in-situ treatment. However, current microneedles rely on passive …
painlessness, and precise in-situ treatment. However, current microneedles rely on passive …
The micro (nano) plastics perspective: exploring cancer development and therapy
X Deng, Y Gui, L Zhao - Molecular Cancer, 2025 - Springer
Microplastics, as an emerging environmental pollutant, have received widespread attention
for their potential impact on ecosystems and human health. Microplastics are defined as …
for their potential impact on ecosystems and human health. Microplastics are defined as …
Dysregulated ribosome quality control in human diseases
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …
Systematic optimization of automated phosphopeptide enrichment for high-sensitivity phosphoproteomics
Improving coverage, robustness, and sensitivity is crucial for routine phosphoproteomics
analysis by single-shot liquid chromatography-tandem mass spectrometry (LC-MS/MS) from …
analysis by single-shot liquid chromatography-tandem mass spectrometry (LC-MS/MS) from …
SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma
B Miao, L Ge, C He, X Wang, J Wu, X Li, K Chen, J Wan… - Cell research, 2024 - nature.com
While lysine methylation is well-known for regulating gene expression transcriptionally, its
implications in translation have been largely uncharted. Trimethylation at lysine 22 …
implications in translation have been largely uncharted. Trimethylation at lysine 22 …
[HTML][HTML] Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells
B Li, W Li, Y Liao, Z Weng, Y Chen, T Ouchi… - Journal of Advanced …, 2024 - Elsevier
Introduction The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth
to the alveolar bone, enables tooth retention and facilitates continuous turnover. The …
to the alveolar bone, enables tooth retention and facilitates continuous turnover. The …
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic
effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its …
effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its …
Oocytes maintain low ROS levels to support the dormancy of primordial follicles
S Qin, X Chi, Z Zhu, C Chen, T Zhang, M He… - Aging …, 2025 - Wiley Online Library
Primordial follicles (PFs) function as the long‐term reserve for female reproduction,
remaining dormant in the ovaries and becoming progressively depleted with age. Oxidative …
remaining dormant in the ovaries and becoming progressively depleted with age. Oxidative …
Death by ribosome
Next to their essential role as protein production factories, ribosomes serve as molecular
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …