Ultrasound‐activated probiotics vesicles coating for titanium implant infections through bacterial cuproptosis‐like death and immunoregulation

S Li, Y Yue, W Wang, M Han, X Wan, Q Li… - Advanced …, 2024 - Wiley Online Library
Implant‐associated infections (IAIs) are the main cause of prosthetic implant failure.
Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in …

Microorganism microneedle micro-engine depth drug delivery

B Zheng, Q Li, L Fang, X Cai, Y Liu, Y Duo, B Li… - Nature …, 2024 - nature.com
As a transdermal drug delivery method, microneedles offer minimal invasiveness,
painlessness, and precise in-situ treatment. However, current microneedles rely on passive …

The micro (nano) plastics perspective: exploring cancer development and therapy

X Deng, Y Gui, L Zhao - Molecular Cancer, 2025 - Springer
Microplastics, as an emerging environmental pollutant, have received widespread attention
for their potential impact on ecosystems and human health. Microplastics are defined as …

Dysregulated ribosome quality control in human diseases

T McGirr, O Onar, SM Jafarnejad - The FEBS Journal, 2024 - Wiley Online Library
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …

Systematic optimization of automated phosphopeptide enrichment for high-sensitivity phosphoproteomics

P Bortel, I Piga, C Koenig, C Gerner… - Molecular & Cellular …, 2024 - ASBMB
Improving coverage, robustness, and sensitivity is crucial for routine phosphoproteomics
analysis by single-shot liquid chromatography-tandem mass spectrometry (LC-MS/MS) from …

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

B Miao, L Ge, C He, X Wang, J Wu, X Li, K Chen, J Wan… - Cell research, 2024 - nature.com
While lysine methylation is well-known for regulating gene expression transcriptionally, its
implications in translation have been largely uncharted. Trimethylation at lysine 22 …

[HTML][HTML] Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells

B Li, W Li, Y Liao, Z Weng, Y Chen, T Ouchi… - Journal of Advanced …, 2024 - Elsevier
Introduction The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth
to the alveolar bone, enables tooth retention and facilitates continuous turnover. The …

Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil

S Chatterjee, P Naeli, O Onar, N Simms… - Nucleic Acids …, 2024 - academic.oup.com
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic
effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its …

Oocytes maintain low ROS levels to support the dormancy of primordial follicles

S Qin, X Chi, Z Zhu, C Chen, T Zhang, M He… - Aging …, 2025 - Wiley Online Library
Primordial follicles (PFs) function as the long‐term reserve for female reproduction,
remaining dormant in the ovaries and becoming progressively depleted with age. Oxidative …

Death by ribosome

AC Vind, FL Zhong, S Bekker-Jensen - Trends in Cell Biology, 2024 - cell.com
Next to their essential role as protein production factories, ribosomes serve as molecular
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …