Acute kidney injury (AKI) is a contributing factor in the development and progression of
chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI …

Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the
gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can …

After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …

Abstract Knowledge of cell type composition in disease relevant tissues is an important step
towards the identification of cellular targets of disease. We present MuSiC, a method that …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

The ability to reliably and reproducibly measure any protein of the human proteome in any
tissue or cell type would be transformative for understanding systems-level properties as …

Scars are more severe when the subcutaneous fascia beneath the dermis is injured upon
surgical or traumatic wounding. Here, we present a detailed analysis of fascia cell …

The underlying cellular events driving kidney fibrogenesis and metabolic dysfunction are
incompletely understood. Here, we employed single-cell combinatorial indexing RNA …

Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

Kidney fibrosis constitutes the shared final pathway of nearly all chronic nephropathies, but
biomarkers for the non-invasive assessment of kidney fibrosis are currently not available. To …