[HTML][HTML] Nrf2: An all-rounder in depression

C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022‏ - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

V Dionisie, GA Filip, MC Manea, M Manea… - Inflammopharmacology, 2021‏ - Springer
Rationale Depression has the topmost prevalence of all psychiatric diseases. It is
characterized by a high recurrence rate, disability, and numerous and mostly unclear …

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

U Gupta, S Ghosh, CT Wallace, P Shang, Y **n… - Autophagy, 2023‏ - Taylor & Francis
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

CG Hsu, CL Chávez, C Zhang, M Sowden… - Cell Death & …, 2022‏ - nature.com
Pyroptosis is a form of cell death triggered by the innate immune system that has been
implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level …

Inhibition of S100A8/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy

L Du, Y Chen, J Shi, X Yu, J Zhou, X Wang, L Xu, J Liu… - Metabolism, 2023‏ - Elsevier
Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

W Li, T Ali, C Zheng, Z Liu, K He, FA Shah… - Journal of …, 2021‏ - Springer
Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2

Y Guan, J Wang, X Wu, L Song, Y Wang, M Gong, B Li - Brain Research, 2021‏ - Elsevier
Quercetin is a flavonoid compound rich in many natural plants with a wide range of
pharmacological effects and nutritional value. Although previous studies have initially shown …

[HTML][HTML] Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral …

Y **, H Pang, L Zhao, F Zhao, Z Cheng, Q Liu, R Cui… - Phytomedicine, 2022‏ - Elsevier
Background Shenfu decoction (SFD) is a classic Chinese medicine prescription that has a
strong cardiotonic effect. The combination of ginseng (the dried root of Panax ginseng CA …

Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder

L Wang, R Xu, C Huang, G Yi, Z Li, H Zhang… - General …, 2023‏ - pmc.ncbi.nlm.nih.gov
Depression is a major contributor to poor global health and disability, with a recently
increasing incidence. Although drug therapy is commonly used to treat depression …

Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through …

K Abu-Elfotuh, AH Al-Najjar, AA Mohammed… - International …, 2022‏ - Elsevier
Depression is a risk factor for Alzheimer's (AD) and cardiovascular diseases (CVD).
Therefore, depression treatment restricts its deteriorating effects on mood, memory and CV …