Simple Summary The sequence–structure–function paradigm, which emphasizes the
relationship between the 3D structure and functions of a protein, is a core concept in biology …

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
spread worldwide, caused a global pandemic, and killed millions of people. The spike …

ATP-citrate lyase (ACLY) is a critical metabolic enzyme and promising target for drug
development. The structure determinations of ACLY have revealed its homotetramer states …

Membrane proteins play crucial roles in various physiological processes, including molecule
transport across membranes, cell communication, and signal transduction. Approximately …

Membrane asymmetry is critical for maintenance of several different processes such as cell
signaling, apoptosis, and vesicular transport in various eukaryotic systems. Flippases of the …