The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance

MA Iqbal, S Arora, G Prakasam, GA Calin… - Molecular aspects of …, 2019 - Elsevier
Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay

AS Doghish, A Ismail, MA Elrebehy… - … -Research and Practice, 2022 - Elsevier
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …

Targeted MDM2 degradation reveals a new vulnerability for p53-inactivated triple-negative breast cancer

CM Adams, R Mitra, Y **ao, P Michener, J Palazzo… - Cancer discovery, 2023 - AACR
Triple-negative breast cancers (TNBC) frequently inactivate p53, increasing their
aggressiveness and therapy resistance. We identified an unexpected protein vulnerability in …

Targeting noncoding RNAs in disease

BD Adams, C Parsons, L Walker… - The Journal of …, 2017 - Am Soc Clin Investig
Many RNA species have been identified as important players in the development of chronic
diseases, including cancer. Over the past decade, numerous studies have highlighted how …

Lung cancer epigenetics: from knowledge to applications

M Duruisseaux, M Esteller - Seminars in cancer biology, 2018 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

Dual role of microRNA-31 in human cancers; focusing on cancer pathogenesis and signaling pathways

P Rodrigues, JA Rizaev, A Hjazi, FMA Altalbawy… - Experimental Cell …, 2024 - Elsevier
Widespread changes in the expression of microRNAs in cancer result in abnormal gene
expression for the miRNAs that control those genes, which in turn causes changes to entire …

Methylated circulating tumor DNA in blood: power in cancer prognosis and response

K Warton, KL Mahon, G Samimi - Endocrine-related cancer, 2016 - erc.bioscientifica.com
The aim of the present study was to perform a systematic review of published studies to
provide a robust estimation of the use of procalcitonin (ProCT) as a diagnostic marker of …

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK …

F Yu, M Liang, Y Huang, W Wu, B Zheng… - Journal of Experimental & …, 2021 - Springer
Background Exosomes have emerged as critical mediators of intercellular communication.
Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly …

Frontiers of MicroRNA signature in non-small cell lung cancer

X Zhu, M Kudo, X Huang, H Sui, H Tian… - Frontiers in Cell and …, 2021 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell
lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases. Recent …