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The changing metabolic landscape of bile acids–keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …
maintain gut microbial community composition and mediate inflammation, and they serve as …
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Q Nie, X Luo, K Wang, Y Ding, S Jia, Q Zhao, M Li… - Cell, 2024 - cell.com
The gut microbiota has been found to play an important role in the progression of metabolic
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
The underappreciated diversity of bile acid modifications
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial
metabolism remains incompletely characterized. To address this knowledge gap, we …
metabolism remains incompletely characterized. To address this knowledge gap, we …
Optimal Approaches to Treating and Preventing Acute and Chronic Pouchitis by Altering Microbial Profiles
G Kallumkal, EL Barnes - Gastroenterology Clinics, 2025 - gastro.theclinics.com
The advancement of immunobiologic therapy for ulcerative colitis (UC) has drastically
altered the management of refractory disease. Many patients who would require surgical …
altered the management of refractory disease. Many patients who would require surgical …
Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient
ABSTRACT Bacteroides fragilis comprises 1%–5% of the gut microbiota in healthy humans
but can expand to> 50% of the population in ulcerative colitis (UC) patients experiencing …
but can expand to> 50% of the population in ulcerative colitis (UC) patients experiencing …
Multi-omics analysis of a Bacteroides fragilis isolate from an ulcerative colitis patient defines genetic determinants of fitness in bile
Abstract Bacteroides fragilis comprises 1-5% of the gut microbiota in healthy individuals but
can expand to> 50% of the population in ulcerative colitis (UC) patients experiencing …
can expand to> 50% of the population in ulcerative colitis (UC) patients experiencing …