In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has
been increasingly viewed as a significant modifiable risk factor for diseases such as …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

With ageing, bone tissue undergoes significant compositional, architectural and metabolic
alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone …

Exercise can prevent and improve the pathophysiology of diseases and promote healthy
aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise …

Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

Adipocytes were identified in human bone marrow more than a century ago, yet until
recently little has been known about their origin, development, function or interactions with …

Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

Bone marrow adipose tissue (BMAT) emerges as a distinct fat depot whose importance has
been proved in the bone–fat interaction. Indeed, it is well recognized that adipokines and …

A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

The presence of adipocytes in mammalian bone marrow (BM) has been recognized
histologically for decades, yet, until recently, these cells have received little attention from …