The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

Human genome function is underpinned by the primary storage of genetic information in
canonical B-form DNA, with a second layer of DNA structure providing regulatory control. I …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

C‐rich DNA has the capacity to form a tetra‐stranded structure known as an i‐motif. The i‐
motifs within genomic DNA have been proposed to contribute to the regulation of DNA …

We study here a DNA oligonucleotide having the ability to form two different i-motif structures
whose relative stability depends on pH and temperature. The major species at neutral pH is …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …

Recent studies indicate that i‐DNA, a four‐stranded cytosine‐rich DNA also known as the i‐
motif, is actually formed in vivo; however, a systematic study on sequence effects on stability …