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Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications
Individuals living with HIV who are optimally treated with combination antiretroviral therapy
(cART) can now lead an extended life. In spite of this remarkable survival benefit from viral …
(cART) can now lead an extended life. In spite of this remarkable survival benefit from viral …
Microglial physiology: unique stimuli, specialized responses
Microglia, the macrophages of the central nervous system parenchyma, have in the normal
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …
The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function
The innate immune system is strongly implicated in the pathogenesis of Alzheimer's disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …
Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection
CB Sturdevant, SB Joseph, G Schnell, RW Price… - PLoS …, 2015 - journals.plos.org
Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …
provides a foundation for neurocognitive impairment and a potentially important tissue …
HIV-1 replication in the central nervous system occurs in two distinct cell types
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can lead to the development of HIV-1-associated dementia (HAD). We examined the …
can lead to the development of HIV-1-associated dementia (HAD). We examined the …
HIV-1 infection and cognitive impairment in the cART era: a review
With the introduction of combination antiretroviral therapy AIDS dementia complex or HIV-
associated dementia, as it was termed later, largely disappeared in clinical practice …
associated dementia, as it was termed later, largely disappeared in clinical practice …
Global research priorities for infections that affect the nervous system
Infections that cause significant nervous system morbidity globally include viral (for example,
HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus …
HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus …
Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis
ABSTRACT HIV continues to be a global health crisis with more than 34 million people
infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World …
infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World …
Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders
HIV infected people are living longer due to the success of combined antiretroviral therapy
(cART). However, greater than 40-70% of HIV infected individuals develop HIV associated …
(cART). However, greater than 40-70% of HIV infected individuals develop HIV associated …
[HTML][HTML] New challenges of HIV-1 infection: how HIV-1 attacks and resides in the central nervous system
Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating
pandemics in recorded history. The main causal agent of AIDS is the human …
pandemics in recorded history. The main causal agent of AIDS is the human …