Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Nanobuffering of pH-responsive polymers: a known but sometimes overlooked phenomenon and its biological applications

W Tao, J Wang, WJ Parak, OC Farokhzad, J Shi - ACS nano, 2019 - ACS Publications
With recent advances in polymer chemistry, materials science, and nanotechnology, pH-
responsive polymers have a significant impact in a number of diverse fields. Fundamental …

Effect of polypeptide complex coacervate microenvironment on protonation of a guest molecule

S Choi, AR Knoerdel, CE Sing… - The Journal of Physical …, 2023 - ACS Publications
Complex coacervate droplets formed by the liquid–liquid phase separation of polyelectrolyte
solutions capture several important features of membraneless organelles including their …

Thermoresponsive Dendronized Microgels through In Situ Cross-Linking Polymerization to Exhibit Enhanced Confinement for Solvatochromic Dyes

J Zhang, Y Yao, Y Zhang, D Wu, W Li… - …, 2023 - ACS Publications
Polymeric microgels form a class of promising materials for various applications based on
their highly tunable swelling and cooperative interactions between the cross-linked polymer …

Transforming protein-polymer conjugate purification by tuning protein solubility

SL Baker, A Munasinghe, B Kaupbayeva… - Nature …, 2019 - nature.com
Almost all commercial proteins are purified using ammonium sulfate precipitation. Protein-
polymer conjugates are synthesized from pure starting materials, and the struggle to …

Metal–phenolic networks as tunable buffering systems

J Chen, S Pan, J Zhou, R Seidel, S Beyer… - Chemistry of …, 2021 - ACS Publications
The buffering effects displayed by pH-responsive polymers have recently gained attention in
diverse fields such as nanomedicine and water treatment. However, creating libraries of …

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

T Schulte, MD Panas, X Han, L Williams… - Open …, 2023 - royalsocietypublishing.org
G3BP is the central node within stress-induced protein–RNA interaction networks known as
stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually …

Confined microenvironments from thermoresponsive dendronized polymers

G Xu, K Liu, B Xu, Y Yao, W Li, J Yan… - Macromolecular Rapid …, 2020 - Wiley Online Library
Confined microenvironments in biomacromolecules arising from molecular crowding
account for their well‐defined biofunctions and bioactivities. To mimick this, synthetic …

Quantitative prediction of charge regulation in oligopeptides

R Lunkad, A Murmiliuk, P Hebbeker… - … Systems Design & …, 2021 - pubs.rsc.org
Weak ampholytes are ubiquitous in nature and commonly found in artificial pH-responsive
systems. However, our limited understanding of their charge regulation and the lack of …

One-pot synthesis to prepare lignin/photoacid nanohybrids for multifunctional biosensors and photo-triggered singlet oxygen generation

TSE Ho-Yin, CS Yeung, CY Lau, MY Cheung… - Green …, 2022 - pubs.rsc.org
This study presents a green, simple, and efficient one-pot synthesis approach for a
sustainable lignin nanoparticle biosensor (AL-Por-PP). Lignin was incorporated in a typical …