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Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
Monotopic membrane proteins join the fold
Monotopic membrane proteins, classified by topology, are proteins that embed into a single
face of the membrane. These proteins are generally underrepresented in the Protein Data …
face of the membrane. These proteins are generally underrepresented in the Protein Data …
Membrane protein mobility and orientation preserved in supported bilayers created directly from cell plasma membrane blebs
MJ Richards, CY Hsia, RR Singh, H Haider, J Kumpf… - Langmuir, 2016 - ACS Publications
Membrane protein interactions with lipids are crucial for their native biological behavior, yet
traditional characterization methods are often carried out on purified protein in the absence …
traditional characterization methods are often carried out on purified protein in the absence …
Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains
Z Yang, C Wang, Q Zhou, J An, E Hildebrandt… - Protein …, 2014 - Wiley Online Library
Detergent interaction with extramembranous soluble domains (ESDs) is not commonly
considered an important determinant of integral membrane protein (IMP) behavior during …
considered an important determinant of integral membrane protein (IMP) behavior during …
New frontiers for selective biosensing with biomembrane-based organic transistors
Biosensing plays vital roles in multiple fields, including healthcare monitoring, drug
screening, disease diagnosis, and environmental pollution control. In recent years, transistor …
screening, disease diagnosis, and environmental pollution control. In recent years, transistor …
A molecularly complete planar bacterial outer membrane platform
The bacterial outer membrane (OM) is a barrier containing membrane proteins and
liposaccharides that fulfill crucial functions for Gram-negative bacteria. With the advent of …
liposaccharides that fulfill crucial functions for Gram-negative bacteria. With the advent of …
A review of traditional and emerging methods to characterize lipid–protein interactions in biological membranes
Current understanding of the cell membrane suggests that it is a patchwork structure
composed of many proteins and lipids that are not all freely diffusing, but rather can take part …
composed of many proteins and lipids that are not all freely diffusing, but rather can take part …
Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA
In selected Campylobacter species, the biosynthesis of N‐linked glycoconjugates via the pgl
pathway is essential for pathogenicity and survival. However, most of the membrane …
pathway is essential for pathogenicity and survival. However, most of the membrane …
Kinetics and thermodynamics of membrane protein folding
Understanding protein folding has been one of the great challenges in biochemistry and
molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have …
molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have …
Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network
A central question in animal evolution is how multicellular animals evolved from unicellular
ancestors. We hypothesize that membrane proteins must be key players in the development …
ancestors. We hypothesize that membrane proteins must be key players in the development …