Strategies for delivering therapeutics across the blood–brain barrier

GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery

MC Teixeira, C Carbone, EB Souto - Progress in lipid research, 2017 - Elsevier
Solid lipid nanoparticle (SLN), nanostructured lipid carriers (NLC) and hybrid nanoparticles,
have gained increasing interest as drug delivery systems because of their potential to load …

Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity

R Vieira, P Severino, LA Nalone, SB Souto, AM Silva… - Molecules, 2020 - mdpi.com
Essential oils are odorant liquid oily products consisting of a complex mixture of volatile
compounds obtained from a plant raw material. They have been increasingly proven to act …

Self-assembling drug formulations with tunable permeability and biodegradability

G Gaynanova, L Vasileva, R Kashapov, D Kuznetsova… - Molecules, 2021 - mdpi.com
This review focuses on key topics in the field of drug delivery related to the design of
nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability …

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

TN Pashirova, IV Zueva, KA Petrov… - Colloids and surfaces B …, 2018 - Elsevier
New mixed cationic liposomes based on L-α-phosphatidylcholine and
dihexadecylmethylhydroxyethylammonium bromide (DHDHAB) were designed to overcome …

[HTML][HTML] Graphene oxide encapsulated 3D porous chalcopyrite (CuFeS2) nanocomposite as an emerging electrocatalyst for agro-hazardous (methyl paraoxon) …

U Rajaji, K Murugan, SM Chen, M Govindasamy… - Composites Part B …, 2019 - Elsevier
Methyl paraoxon (MOX) is a highly toxic organophosphate pesticide. It is recently reported
that, MOX can enter the human body through ingestion, inhalation, or by dermal penetration …

A brief survey on the advanced brain drug administration by nanoscale carriers: with a particular focus on AChE reactivators

S Parvaz, R Taheri-Ledari, MS Esmaeili, M Rabbani… - Life sciences, 2020 - Elsevier
Obviously, delivery of the medications to the brain is more difficult than other tissues due to
the existence of a strong obstacle, which is called blood-brain barrier (BBB). Because of the …

Nanoparticle strategies to improve the delivery of anticancer drugs across the blood–brain barrier to treat brain tumors

WJF Vanbilloen, JS Rechberger, JB Anderson… - Pharmaceutics, 2023 - mdpi.com
Primary brain and central nervous system (CNS) tumors are a diverse group of neoplasms
that occur within the brain and spinal cord. Although significant advances in our …

Lipid nanostructures for targeting brain cancer

H Nsairat, D Khater, F Odeh, F Al-Adaileh, S Al-Taher… - Heliyon, 2021 - cell.com
Advancements in both material science and bionanotechnology are transforming the health
care sector. To this end, nanoparticles are increasingly used to improve diagnosis …

Treating organophosphates poisoning: management challenges and potential solutions

M Alozi, M Rawas-Qalaji - Critical reviews in toxicology, 2020 - Taylor & Francis
Organophosphorus agents (OP) are widely used as pesticides due to their cost
effectiveness, yet they present a significant public health risk owing to their high toxicity …