Motivation The theoretical possibility of determining the state and parameters of a dynamic
model by measuring its outputs is given by its structural identifiability and its observability …

Mechanistic dynamical models allow us to study the behavior of complex biological systems.
They can provide an objective and quantitative understanding that would be difficult to …

Antimicrobial heteroresistance refers to the presence of different subpopulations with
heterogeneous antimicrobial responses within the same bacterial isolate, so they show …

Constructing dynamic mathematical models of biological systems requires estimating
unknown parameters from available experimental data, usually using a statistical fitting …

Introduction: Several signaling pathways are activated during hypoxia to promote
angiogenesis, leading to endothelial cell patterning, interaction, and downstream signaling …

Background: We address the problem of determining the controllability and accessibility of
nonlinear biosystems. We consider models described by affine-in-inputs ordinary differential …

Motivation Dynamic mechanistic modelling in systems biology has been hampered by the
complexity and variability associated with the underlying interactions, and by uncertain and …

Interpreting data with mathematical models is an important aspect of real-world applied
mathematical modeling. Very often we are interested to understand the extent to which a …

Controller motifs are simple biomolecular reaction networks with negative feedback. They
can explain how regulatory function is achieved and are often used as building blocks in …

The concept of identifiability describes the possibility of inferring the parameters of a
dynamic model by observing its output. It is common and useful to distinguish between …