The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …

At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

The intestinal microbiota has become a relevant aspect of human health. Microbial
colonization runs in parallel with immune system maturation and plays a role in intestinal …

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …

The immune cells that reside at the interface between the placenta and uterus are thought to
play many important roles in pregnancy. Recent work has revealed that the composition and …

The differences between males and females begin shortly after birth, continue throughout
prenatal development, and eventually extend into childhood and adult life. Male embryos …

An improved mechanistic understanding of the adaptational processes mounted during
mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal …

The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …