Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control
L Lu, M **e, B Yang, W Zhao, J Cao - Science Advances, 2024 - science.org
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …
therapy for cancer that has demonstrated notable potential in clinical applications. However …
CAR T therapies in multiple myeloma: Unleashing the future
In recent years, the field of cancer treatment has witnessed remarkable breakthroughs that
have revolutionized the landscape of care for cancer patients. While traditional pillars such …
have revolutionized the landscape of care for cancer patients. While traditional pillars such …
Infusion and delivery strategies to maximize the efficacy of CAR-T cell immunotherapy for cancers
X Gu, Y Zhang, W Zhou, F Wang, F Yan, H Gao… - … Hematology & Oncology, 2024 - Springer
Chimeric antigen receptor (CAR) T-cell therapy has achieved substantial clinical outcomes
for tumors, especially for hematological malignancies. However, extending the duration of …
for tumors, especially for hematological malignancies. However, extending the duration of …
Immunotherapy of multiple myeloma: current status as prologue to the future
HN Abramson - International Journal of Molecular Sciences, 2023 - mdpi.com
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic
shift since the dawn of the current century. This has been driven largely by the introduction of …
shift since the dawn of the current century. This has been driven largely by the introduction of …
Potency assays and biomarkers for cell-based advanced therapy medicinal products
C Capelli, C Cuofano, C Pavoni, S Frigerio… - Frontiers in …, 2023 - frontiersin.org
Advanced Therapy Medicinal Products (ATMPs) based on somatic cells expanded in vitro,
with or without genetic modification, is a rapidly growing area of drug development, even …
with or without genetic modification, is a rapidly growing area of drug development, even …
Effectiveness and safety of anti-BCMA chimeric antigen receptor T-cell treatment in relapsed/refractory multiple myeloma: a comprehensive review and meta-analysis …
D Hu, L Chen, D Yan, W Dong, M Chen… - Frontiers in …, 2023 - frontiersin.org
Background: Chimeric antigen receptor T cells treatment targeting B cell maturation antigen
(BCMA) is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) …
(BCMA) is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) …
The impact of outpatient versus inpatient administration of CAR-T therapies on clinical, economic, and humanistic outcomes in patients with hematological cancer: A …
DK Hansen, YH Liu, S Ranjan, H Bhandari, R Potluri… - Cancers, 2023 - mdpi.com
Simple Summary The administration of chimeric antigen receptor (CAR)-T cell therapies in
an outpatient setting is expanding; however, there is limited evidence comparing outcomes …
an outpatient setting is expanding; however, there is limited evidence comparing outcomes …
Anoikis in cell fate, physiopathology, and therapeutic interventions
The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a
particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis …
particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis …
BCMA-directed therapy, new treatments in the myeloma toolbox, and how to use them
MJ Rees, S Kumar - Leukemia & Lymphoma, 2024 - Taylor & Francis
To address the dearth of therapeutic options available for relapsed-refractory multiple
myeloma (RRMM), attention has shifted to immunotherapeutic strategies, with most products …
myeloma (RRMM), attention has shifted to immunotherapeutic strategies, with most products …
Leukapheresis for CAR-T cell production and therapy
Chimeric antigen receptor (CAR) T-cell therapy is an effective, individualized
immunotherapy, and novel treatment for hematologic malignancies. Six commercial CAR-T …
immunotherapy, and novel treatment for hematologic malignancies. Six commercial CAR-T …