Cancer genomics efforts have identified genes and regulatory elements driving cancer
development and neoplastic progression. From a microevolution standpoint, these are …

Background: Loss of tumor suppressor gene p16 expression via promoter methylation has
been reported in hepatocellular carcinoma (HCC). This meta-analysis was conducted to …

Background The five-year overall survival (OS) of advanced-stage ovarian cancer remains
nearly 25-35%, although several treatment strategies have evolved to get better outcomes. A …

Simple Summary Cancer develops due to the expression of genes that promote cell growth
and the repression of genes that limit growth. Epigenetics is a mechanism that regulates …

OBJECTIVE: Glioma is a tumor of the brain. Although the clinical regimens and surgical
techniques for glioma have improved, therapies of advanced glioma remain challenging …

The RBL2 locus has been associated with intelligence and educational attainment but not
with a monogenic disorder to date. RBL2 encodes p130, a member of the retinoblastoma …

Dynamic positioning of nucleosomes is pivotal in determining level of genes expression
especially on or around transcription start site (TSS) of a gene. Purpose of the current study …

E2F4 is an important basal transcription factor with the potential to promote tumor growth. Its
upregulation in various types of cancer has been linked to numerous genetic factors; …

With a purpose of accurate and simultaneous determination of DNA methylation from
multiple loci in multiple samples, here, we are demonstrating a method to aid rapid DNA …

Background Tumor suppressor gene cyclin-dependent kinase inhibitor 2B (p15 (INK4B))
methylation has been frequently reported in myelodysplastic syndromes (MDS). However …