Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

With the increasing world population, demand for industrialization has also increased to
fulfill humans' living standards. Fungi are considered a source of essential constituents to …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …

Abstract The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to
unfold ubiquitylated proteins in many areas of eukaryotic cell biology. In yeast, Cdc48-Ufd1 …

Defects in cellular proteostasis and mitochondrial function drive many aspects of infertility,
cancer, and other age-related diseases. All of these conditions rely on quiescent cells, such …

Ferroptosis is an iron-dependent form of programmed cell death, which plays crucial roles in
tumorigenesis, ischemia–reperfusion injury and various human degenerative diseases …

Degrader technologies, which enable the chemical knockdown of disease-causing proteins,
are promising for drug discovery. After two decades of research, degraders using the …

The degradation of damaged proteins is critical for tissue integrity and organismal health
because damaged proteins have a high propensity to form aggregates. E3 ubiquitin ligases …

Ubiquitin-dependent control of mitochondrial dynamics is important for protein quality and
neuronal integrity. Mitofusins, mitochondrial fusion factors, can integrate cellular stress …

Ageing is an unavoidable multi-factorial process, characterised by a gradual decrease in
physiological functionality and increasing vulnerability of the organism to environmental …