Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

Histone deacetylases (HDACs) decrease the acetylation level of histones and other non-
histone proteins. Over expression of HDACs have been observed in cancers and other …

One consequence of modern cancer therapy is chemotherapy related cognitive dysfunction
or “chemobrain”, the subjective experience of cognitive deficits at any point during or …

During development of the nervous system, the formation of connections (synapses)
between neurons is dependent upon electrical activity in those neurons, and neurotrophic …

Schizophrenia is considered primarily as a cognitive disorder. However, functional
outcomes in schizophrenia are limited by the lack of effective pharmacological and …

Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

Neuropsychiatric pathologies, including neurodegenerative diseases and
neurodevelopmental syndromes, are frequently associated with dysregulation of various …

Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are
projected to lead global disease burden within the next decade. Pharmacotherapy, the …