Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

R Yehuda, A Lehrner - World psychiatry, 2018 - Wiley Online Library
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

Intergenerational transmission of stress in humans

ME Bowers, R Yehuda - Neuropsychopharmacology, 2016 - nature.com
The hypothesis that offspring are affected by parental trauma or stress exposure, first noted
anecdotally, is now supported empirically by data from Holocaust survivor offspring cohorts …

Holocaust exposure induced intergenerational effects on FKBP5 methylation

R Yehuda, NP Daskalakis, LM Bierer, HN Bader… - Biological …, 2016 - Elsevier
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring

R Yehuda, NP Daskalakis, A Lehrner… - American Journal of …, 2014 - psychiatryonline.org
Objective Differential effects of maternal and paternal posttraumatic stress disorder (PTSD)
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …

Stress, female reproduction and pregnancy

G Valsamakis, G Chrousos, G Mastorakos - Psychoneuroendocrinology, 2019 - Elsevier
Stress is one of the commonest and underappreciated causes of reproductive frailty in
women. The stress system leads to adaptive responses via mobilization of hormonal …

Parental advisory: maternal and paternal stress can impact offspring neurodevelopment

JC Chan, BM Nugent, TL Bale - Biological psychiatry, 2018 - Elsevier
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …

Prenatal stress, glucocorticoids, and developmental programming of the stress response

PO McGowan, SG Matthews - Endocrinology, 2018 - academic.oup.com
The early environment has a major impact on the develo** embryo, fetus, and infant.
Parental adversity (maternal and paternal) and glucocorticoid exposure before conception …

Intergenerational effect of maternal exposure to childhood maltreatment on newborn brain anatomy

NK Moog, S Entringer, JM Rasmussen, M Styner… - Biological …, 2018 - Elsevier
Background Childhood maltreatment (CM) confers deleterious long-term consequences,
and growing evidence suggests some of these effects may be transmitted across …

Cultural trauma and epigenetic inheritance

A Lehrner, R Yehuda - Development and psychopathology, 2018 - cambridge.org
The question of whether and how the effects of cultural trauma can be transmitted
intergenerationally from parents to offspring, or even to later generations, has evoked …

Trauma across generations and paths to adaptation and resilience.

A Lehrner, R Yehuda - Psychological trauma: theory, research …, 2018 - psycnet.apa.org
Objective: There is a growing literature on the intergenerational transmission of trauma,
representing approaches across psychodynamic, family systems, epidemiological …